The COVID-19 pandemic has provided a dramatic illustration of the extent to which the health of people, animals and the environment is interdependent, which is why “One Health” is now high on the political agenda. This document provides an overview of KfW Development Bank’s approach to promoting human, animal and environmental health. Involvement in areas like agriculture, biodiversity, health and water is already contributing to the One Health objectives. Moving forward, it will also be important to give greater consideration to interdependencies between sectors and ensure that structural connections are taken into account in cross-sectoral programmes.